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Pregled bibliografske jedinice broj: 323442

Helicobacter pylori infection in patients with Brunner's gland adenoma

Kovačević, Igor; Ljubičić, Neven; Čupić, Hrvoje; Doko, Marko; Zovak, Mario; Troskot, Branko; Kujundžić, Milan; Banić, Marko
Helicobacter pylori infection in patients with Brunner's gland adenoma // Acta medica Croatica, 55 (2001), 157-160 (međunarodna recenzija, članak, znanstveni)

Helicobacter pylori infection in patients with Brunner's gland adenoma

Kovačević, Igor ; Ljubičić, Neven ; Čupić, Hrvoje ; Doko, Marko ; Zovak, Mario ; Troskot, Branko ; Kujundžić, Milan ; Banić, Marko

Acta medica Croatica (1330-0164) 55 (2001); 157-160

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brunner's gland adenoma; duodenal polyp; Helicobacter pylori

Histopathologic and clinical data strongly suggest a causal relation between Helicobacter pylori infection and gastritis, peptic ulcer disease, or both. However, little has been written about the potential association between H. pylori infection and Brunner's gland adenoma. Therefore, we carried out a prospective study to determine the presence of H. pylori infection among patients with Brunner's gland adenoma. From November 1996 till October 1999, 19100 patients who had undergone upper gastrointestinal endoscopy at two clinical centers in Zagreb, Croatia, were candidates for participation in the study. Brunner's gland adenoma was diagnosed on the basis of histologic samples taken from the polyp (four patients) or after the entire polyp was made available upon endoscopic removal (three patients). When all endoscopic examinations had been performed, biopsy samples were taken from the antrum and body of the stomach, so that gastritis could be classified and H. pylori determinedby histology. Biopsy samples were also taken from the duodenal bulb to verify duodenitis. Two other samples were taken from the antrum for rapid urease test. The patients were considered positive for H. pylori when both histology and rapid urease test were positive. Brunner's gland adenoma was diagnosed in seven patients (five women and two men ; median age, 49 yrs). Five (71 %) patients with diagnosed Brunner's gland adenoma had concurrent H. pylori infection. Duodenitis associated with gastric metaplasia was observed in six patients. Complete eradication of H. pylori was achieved in only two patients. Symptoms dissapeared or markedly diminished in all patients with significant improvement during therapy or immediately upon endoscopic removal of the polyp. Although limited by a very small number of patients, our results suggest that concurrent H. pylori infection is very common in patients with Brunner's gland adenoma. However, the role of H. pylori infection in the pathogenesis and development of Brunner's gland hyperplasia remains unclear.

Izvorni jezik

Znanstvena područja
Kliničke medicinske znanosti


Projekt / tema

Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava"

Časopis indeksira:

  • Scopus

Uključenost u ostale bibliografske baze podataka:

  • EMBASE (Excerpta Medica)