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Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein


Šarac, Helena; Hajnšek, Sanja; Bašić, Silvio; Henigsberg, Neven; Radoš, Marko; Šimić, Goran
Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein // European Journal of Neurology
Brussels, Belgium: EFNS, 2007. str. 58-58 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein

Autori
Šarac, Helena ; Hajnšek, Sanja ; Bašić, Silvio ; Henigsberg, Neven ; Radoš, Marko ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology / - Brussels, Belgium : EFNS, 2007, 58-58

Skup
11th Congress of the European Federation of Neurological Societies (EFNS)

Mjesto i datum
Brisel, Belgija, 25-28.08.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Sporadic Creutzfeldt-Jakob disease; magnetic resonance spectroscopy; tau proteins; cerebrospinal fluid

Sažetak
Over the last several years, it has became clear that electroencephalogram (EEG), magnetic resonance imaging (MRI) and measurement of cerebrospinal fluid (CSF) 14-3-3 proteins are of limited potential in the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). However, some recent reports suggested that magnetic resonance spectroscopy (MRS) and measurement of CSF total tau (t-tau) and phospho-tau (p-tau) proteins could be more useful for ante mortem diagnosis of sCJD. We therefore included these two methods in the diagnostic procedure of a patient with clinically suspected (and later autopsy-proven) sCJD. In contrast to non-specific EEG and MRI findings and negative 14-3-3 proteins in CSF, MRS revealed metabolic alterations in regions of the brain that looked apparently normal on MRI, while tau proteins profiles showed increased levels of both non-phosphorylated and some phosphorylated tau isoforms. We concluded that a combination of serial functional MRI together with MRS and measurement of CSF tau proteins in patients with rapidly progressive dementia syndrome helps to obtain a more reliable early diagnosis of sCJD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Šarac, Helena; Hajnšek, Sanja; Bašić, Silvio; Henigsberg, Neven; Radoš, Marko; Šimić, Goran
Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein // European Journal of Neurology
Brussels, Belgium: EFNS, 2007. str. 58-58 (poster, međunarodna recenzija, sažetak, znanstveni)
Šarac, H., Hajnšek, S., Bašić, S., Henigsberg, N., Radoš, M. & Šimić, G. (2007) Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein. U: European Journal of Neurology.
@article{article, year = {2007}, pages = {58-58}, keywords = {sporadic Creutzfeldt-Jakob disease, magnetic resonance spectroscopy, tau proteins, cerebrospinal fluid}, title = {Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein}, keyword = {sporadic Creutzfeldt-Jakob disease, magnetic resonance spectroscopy, tau proteins, cerebrospinal fluid}, publisher = {EFNS}, publisherplace = {Brisel, Belgija} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE