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Pregled bibliografske jedinice broj: 322748

Hyperserotonemia in autism : the potential role of 5HT-related gene variants


Hranilović, Dubravka; Novak, Ruđer; Babić, Marina; Novokmet, Mislav; Bujas-Petković, Zorana; Jernej, Branimir
Hyperserotonemia in autism : the potential role of 5HT-related gene variants // Collegium Antropologicum, 32 (2008), S1; 75-80 (međunarodna recenzija, članak, znanstveni)


Naslov
Hyperserotonemia in autism : the potential role of 5HT-related gene variants

Autori
Hranilović, Dubravka ; Novak, Ruđer ; Babić, Marina ; Novokmet, Mislav ; Bujas-Petković, Zorana ; Jernej, Branimir

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), S1; 75-80

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Autism; hyperserotonemia; serotonin transporter; tryptophan hydroxylase; monoamine oxidase A; 5HT2A receptor

Sažetak
Increased platelet serotonin level (PSL) has been consistently found in a portion of autistic patients. Suggested mechanisms for hyperserotonemia in autism have been increased synthesisi of serotonin (5HT) by tryptophan hydroxylase (TPH), increased uptake into platelets through 5HT transporter (5HTt), diminished release from platelets through 5HT2A receptor (5HT2A) and decreased metabolism by monoamine oxidase (MAOA). The allelic influence of genes, encoding the mentioned 5HT elements, on PSL was investigated in 63 autistic subjects. Our study shows that 5HTt-LPR and -1438AG 5HT2Ar genotypes did not significantly affect PSL. However, significantly higher PSLs were observed in subjects with "cc" genotype of a218c TPH and subjects with "4" genotype of uVNTR MAOA. In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" genotypes, a correlative increase in PSL was observed with the increase in the number of "high 5HT" genotypes. These results suggest a possible synergistic effect of genes regulating 5HT synthesis/degradation in dysregulation of the peripheral 5HT homeostasis of autistic patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

Napomena
Rad je kao poster prezentiran na skupu Drugi hrvatski kongres neuroznanosti, održanom od 18-19.05.2007., Zagreb, Hrvatska ; objavljen u Knjizi sažetaka u časopisu Neurologia Croatica. Supplement (ISSN 1331-5196) (2007) str. 74.



POVEZANOST RADA


Projekt / tema
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )
119-1081870-2396 - Neurobiološka podloga autizma: uloga serotoninskog sustava (Dubravka Hranilović, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE
  • Sociological Abstracts