Leukotriene receptor antagonists as potential steroid sparing agents in a patient with serosal eosinophilic gastroenteritis (CROSBI ID 136679)
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Podaci o odgovornosti
Crnčević Urek, Marija ; Kujundžić, Milan ; Banić, Marko ; Urek, Roman ; Štoos-Veić, Tajana ; Kardum, Duško
engleski
Leukotriene receptor antagonists as potential steroid sparing agents in a patient with serosal eosinophilic gastroenteritis
Leukotriene receptor antagonist may be useful as steroid sparing agents in patients with the serosal form of gastroenteritis. Eosinophils are potent sources of leukotrienes, including leukotriene C4 and leukotriene D4, molecules known to induce eosinophil chemotaxis, smooth muscle contraction, mucous secretion, and mucosal oedema. Many factors may play a rolein directing eosinophils to a siteof inflammation. These data should challenge our thinking about the treatment of eosinophilic gastrointestinal diseases with new antileukotriene agents, such as leukotriene inhibitors, that provide a more targeted approach to eosinophil derived products.
leukotriene; eosinophilic gastroenteritis; steroid
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Kliničke medicinske znanosti