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Pregled bibliografske jedinice broj: 32205

Bradykinin receptor B2 gene polymorphism and essential hypertension


Ferenčak, Goran; Jelaković, Bojan; Sertić, Jadranka; Kuzmanić, Duško; Čvorišćec, Dubravka; Stavljenić-Rukavina, Ana
Bradykinin receptor B2 gene polymorphism and essential hypertension // Clinical Chemistry and Laboratory Medicine
Firenca, Italija, 1999. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 32205 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bradykinin receptor B2 gene polymorphism and essential hypertension

Autori
Ferenčak, Goran ; Jelaković, Bojan ; Sertić, Jadranka ; Kuzmanić, Duško ; Čvorišćec, Dubravka ; Stavljenić-Rukavina, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / - , 1999

Skup
17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine 1st International Congress of Clinical Molecular Biology (CMB)

Mjesto i datum
Firenca, Italija, 06-11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hypertension; genetics

Sažetak
Bradykinin receptor B2 gene (BDKRB2) is a candidate gene for the molecular marker of inherited predisposition to essential hypertension (EH). It encodes a G-protein linked receptor and there are four known polymorphic sites within the gene. In exon 2 the transition C>T at position 181 of cDNA results in substitution of arginine by cystein at codon 14 (R14C) of the protein. In the promoter region the transition T>C at position 58 upstream is possible, but its effects are still unknown. We investigated the association of these two polymorphisms with EH. The subjects were divided into two groups: normotensives (N=80) and hypertensives (N=80). The polymorphic sites were analysed using PCR/SSCP and RFLP. The C and T alleles at both sites were found to be in Hardy-Weinberg equilibrium and their frequencies were similar to those published for South German population. No significant differencies in the distribution of the genotypes between the two groups were found. Further analysis of the remaining two polymorphic sites is needed in order to rule out this gene as a molecular marker in EH.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108201

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Ferenčak, Goran; Jelaković, Bojan; Sertić, Jadranka; Kuzmanić, Duško; Čvorišćec, Dubravka; Stavljenić-Rukavina, Ana
Bradykinin receptor B2 gene polymorphism and essential hypertension // Clinical Chemistry and Laboratory Medicine
Firenca, Italija, 1999. (poster, međunarodna recenzija, sažetak, znanstveni)
Ferenčak, G., Jelaković, B., Sertić, J., Kuzmanić, D., Čvorišćec, D. & Stavljenić-Rukavina, A. (1999) Bradykinin receptor B2 gene polymorphism and essential hypertension. U: Clinical Chemistry and Laboratory Medicine.
@article{article, year = {1999}, keywords = {hypertension, genetics}, title = {Bradykinin receptor B2 gene polymorphism and essential hypertension}, keyword = {hypertension, genetics}, publisherplace = {Firenca, Italija} }
@article{article, year = {1999}, keywords = {hypertension, genetics}, title = {Bradykinin receptor B2 gene polymorphism and essential hypertension}, keyword = {hypertension, genetics}, publisherplace = {Firenca, Italija} }




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