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Apo B/Apo A-I in prediction of stroke


Bašić Kes, Vanja; Šimundić, Ana-Maria; Nikolac, Nora; Štefanović, Mario; Vargek Solter, Višnja; Trkanjec, Zlatko; Topić, Elizabeta; Demarin, Vida
Apo B/Apo A-I in prediction of stroke // Stroke / Vladimir Hachinski (ur.).
Dallas, Teksas, SAD: American Stroke Association, 2007. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Apo B/Apo A-I in prediction of stroke

Autori
Bašić Kes, Vanja ; Šimundić, Ana-Maria ; Nikolac, Nora ; Štefanović, Mario ; Vargek Solter, Višnja ; Trkanjec, Zlatko ; Topić, Elizabeta ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Stroke / Vladimir Hachinski - Dallas, Teksas, SAD : American Stroke Association, 2007

Skup
2007 International Stroke Conference

Mjesto i datum
San Francisco, Califormia, SAD, 7.-9.2.2007.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Stroke; apolipoproteins; Apo B/Apo A-I

Sažetak
INTRODUCTION: Measuring of total, HDL and LDL cholesterol and triglicerides is not enough to determine one’ s complete lipid status, so this test panel is expanded by measuring apolipoproteins ; mainly Apo B which is part of atherogenic lipoproteins and Apo AI, a component of antiatherogenic HDL particles. Recently, many studies reported that the Apo B/Apo A-I ratio is a better predicting factor for developing cardiovascular events than LDL cholesterol. OBJECTIVE: Aim of this study was to investigate whether a high Apo B/Apo A-I ratio ratio is significantly associated with the risk of developing stroke. METHODS: In our study we evaluated 70 patients with stroke and 68 age and sex matched controls without cerebrovascular deficit. Apo A-I and Apo B were measured by immunoturbidimetric method (Olympus). RESULTS: There was no difference in Apo A-1 (stroke: 1.33 &plusmn ; 0.29 vs control group: 1.41&plusmn ; 0.24 ; P = 0.0724) and Apo B concentration (stroke: 1.02 (0.89-1.16) vs control group: 0.95 (0.84-1.13) ; P=0.2184). Statistically significant difference was found in Apo B/Apo A-I ratio (stroke: 0.83 (0.64-0.93) vs control group: 0.67 (0.57-0.86) ; p= 0.0189). CONCLUSION: A high Apo B/Apo A1 ratio is significantly associated with the risk of developing stroke.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Ana-Maria Šimundić, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE