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Pregled bibliografske jedinice broj: 321482

Comparison of virulence of L. longbeachae strains to other Legionella strains in animal model


Gobin, Ivana; Šantić, Marina; Selenić, Kaća; Šarec, Martina; Šuša, Milorad; Dorić, Miljenko
Comparison of virulence of L. longbeachae strains to other Legionella strains in animal model // International Journal of Sanitary Engineering Research, 2 (2008), 2; 4-10 (podatak o recenziji nije dostupan, članak, znanstveni)


Naslov
Comparison of virulence of L. longbeachae strains to other Legionella strains in animal model

Autori
Gobin, Ivana ; Šantić, Marina ; Selenić, Kaća ; Šarec, Martina ; Šuša, Milorad ; Dorić, Miljenko

Izvornik
International Journal of Sanitary Engineering Research (1854-0678) 2 (2008), 2; 4-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pneumonia; Legionella spp; mice

Sažetak
Legionellae species are one of the causing agents of bacterial pneumonia. Legionella pneumophila accounts for the vast majority of cases in most of the world, with L. micdadei ranking distantly second. Most of the studies has been focused on the understanding the pathogenesis of pneumonia caused by L. pneumophila. Little is know about the virulence of L. longebeache although it’ s leading cause of legionellosis in Austrailia. The aim of this study was to determine the virulence of L. longbeachae in comparison to different Legionella strains including L. pneumophila, L. micdadei and L. steigerwaltii. An animal model of intratracheal infection was established on A/J mice. Our results showed that among all tested strains the most virulent one for mice was L. longbeachae serogroup 1. All the mice that received the dose of 105 cfu of L. pneumophila, L. micdadei, L. longeachae serogrupe 2 or L. steigerwaltii survived and cleared the infection while the mice infected with the same dose of L. longbeachae serogrup 1 developed severe bronchopneumonia and died within five days.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621273-0950 - Francisella tularensis-unutarstanični život i patogeneza tularemije u miša (Marina Šantić, )
062-0621273-1275 - Patogeneza eksperimentalne legioneloze (Miljenko Dorić, )

Ustanove
Medicinski fakultet, Rijeka