engleski

Chromosomal Aberration and Chromosome Y Microdeletion of IVF-ICSI Male Patients

Chromosomal aberrations disturb gamete formation and impair male fertility. The frequency of chromosomal abnormalities in infertile males ranges between 12, 6% and 17, 6%. Since male infertility is largely due to impairment of gametogenesis, in which a number of genes participate, mutations in spermatogenic genes would also result in impaired spermatogenesis, leading to infertility. Recombinant DNA techniques provide the potential for explaining as much as 10% of idiopathic forms of infertility. Deletions in AZF region can cause severe spermatogenic defects ranging from non-obstructive azoospermia to oligozoospermia. The use of intracytoplasmatic sperm injection technique (ICSI) allows AZF deletions to be passed to male offspring. Out of 78 cases examined, 21 had some chromosomal abnormality (26, 9%), while Y-chromosomal microdeletions were found in two of them (2, 56%).

male infertility; chromosomal aberrations; Y chromosome microdeletions

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