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Pregled bibliografske jedinice broj: 318228

Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin


Plohl, Miroslav; Luchetti, Andrea; Meštrović, Nevenka; Mantovani, Barbara
Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin // Gene, 409 (2008), 1-2; 72-82 doi:10.1016/j.gene.2007.11.013 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin

Autori
Plohl, Miroslav ; Luchetti, Andrea ; Meštrović, Nevenka ; Mantovani, Barbara

Izvornik
Gene (0378-1119) 409 (2008), 1-2; 72-82

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
centromere ; concerted evolution ; library model ; pericentromeric heterochromatin ; repetitive sequences

Sažetak
Satellite DNAs (tandemly repeated, non-coding DNA sequences) stretch over almost all native centromeres and surrounding pericentromeric heterochromatin. Once considered as inert by-products of genome dynamics in heterochromatic regions, recent studies showed that satellite DNA evolution is interplay of stochastic events and selective pressure. This points to a functional significance of satellite sequences, which in (peri)centromeres may play some fundamental functional roles. First, specific interactions with DNA-binding proteins are proposed to complement sequence-independent epigenetic processes. The second role is achieved through RNAi mechanism, in which transcripts of satellite sequences initialize heterochromatin formation. In addition, satellite DNAs in (peri)centromeric regions affect chromosomal dynamics and genome plasticity. Paradoxically, while centromeric function is conserved through eukaryotes, the profile of satellite DNAs in this region is almost always species-specific. We argue that tandem repeats may be advantageous forms of DNA sequences in (peri)centromeres due to concerted evolution, which maintains high intra-array and intrapopulation sequence homogeneity of satellite arrays, while allowing rapid changes in nucleotide sequence and/or composition of satellite repeats. This feature may be crucial for long-term stability of DNA-protein interactions in centromeric regions.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
098-0982913-2756 - Evolucija, osobitosti i funkcionalne interakcije sekvenci satelitnih DNA (Plohl, Miroslav, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Plohl, Miroslav; Luchetti, Andrea; Meštrović, Nevenka; Mantovani, Barbara
Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin // Gene, 409 (2008), 1-2; 72-82 doi:10.1016/j.gene.2007.11.013 (međunarodna recenzija, pregledni rad, znanstveni)
Plohl, M., Luchetti, A., Meštrović, N. & Mantovani, B. (2008) Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin. Gene, 409 (1-2), 72-82 doi:10.1016/j.gene.2007.11.013.
@article{article, year = {2008}, pages = {72-82}, DOI = {10.1016/j.gene.2007.11.013}, keywords = {centromere, concerted evolution, library model, pericentromeric heterochromatin, repetitive sequences}, journal = {Gene}, doi = {10.1016/j.gene.2007.11.013}, volume = {409}, number = {1-2}, issn = {0378-1119}, title = {Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin}, keyword = {centromere, concerted evolution, library model, pericentromeric heterochromatin, repetitive sequences} }
@article{article, year = {2008}, pages = {72-82}, DOI = {10.1016/j.gene.2007.11.013}, keywords = {centromere, concerted evolution, library model, pericentromeric heterochromatin, repetitive sequences}, journal = {Gene}, doi = {10.1016/j.gene.2007.11.013}, volume = {409}, number = {1-2}, issn = {0378-1119}, title = {Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin}, keyword = {centromere, concerted evolution, library model, pericentromeric heterochromatin, repetitive sequences} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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