Sedative and anticonvulsant effects of zolpidem in adult and aged mice (CROSBI ID 135457)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Peričić, Danka ; Vlainić Lazić, Josipa ; Švob Štrac Dubravka
engleski
Sedative and anticonvulsant effects of zolpidem in adult and aged mice
To evaluate possible age-related differences in the behavioural effects of zolpidem, a widely used hypnotic, we compared the effects of zolpidem on the locomotor activity and on the seizure threshold for pentylenetetrazole (PTZ) and picrotoxin (given by i.v. infusion) between adult (3 months) and aged (13 months) mice. Zolpidem (10 mg/kg) produced similar enhancements of the seizure threshold in adult and aged mice. The drug was more potent against PTZ- than against picrotoxin-induced seizures. Diazepam (1 mg/kg), which was taken for comparison, had a weaker effect on picrotoxin-induced tonic seizures in aged than in adult mice. Sedative effect of zolpidem (10 mg/kg), as assessed by its effect on the locomotor activity, was very strong in both groups of mice. The results suggest that sedative and antiseizure effects of zolpidem are not changed in aged mice.
zolpidem ; aging ; seizure threshold ; picrotoxin ; pentylenetetrazole ; locomotor activity
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Podaci o izdanju
115 (6)
2008.
795-802
objavljeno
0300-9564
1435-1463
10.1007/s00702-008-0020-0
Povezanost rada
Temeljne medicinske znanosti