engleski

Impact of surgery and cancer removal on oxidative stress parameters in patients with colorectal cancer

Introduction: Reactive oxygen species (ROS) have long been implicated in a large variety of processes and diseases, including carcinogenesis and cancer progression. Moreover, it was suggested the concept of cancer as persistent oxidative stress. The purpose of this clinical study was to evaluate appearance of changes in some markers of oxidative stress in patients with colorectal adenocarcinoma in relation to normal values, also before and after radical surgery. Materials and Methods: Twenty adult patients were studied ; all were affected by colorectal adenocarcinoma in different stages and had undergone surgical treatment. Venous blood samples were obtained 24 hours before surgery and on postoperative days 1, 3 and 7 and one month after surgery for measurement of different systemic parameters. Results: There was no significant difference between colorectal cancer patients and control subjects according to age and gender. Values of SOD activity in sera measured before surgery were lower then on the first day after the operation in patients with colorectal cancer but there were no statistical differences between them. On the third day after the surgery, values of SOD activity in sera were higher than preoperative values (p=0.031), and they reached the highest level during the postoperative period. On the 7th day and one month after the surgery values of SOD activity in sera were also higher then preoperative values, but there were no statistical differences. Values of TAS activity measured before surgery and on the 1st day after the surgery were similar. On the 3rd day after the operation values of TAS activity were significantly lower then before surgery in patients with colorectal cancer (p=0.039) while there were no differences between TAS values measured before surgery, on the 7th day, and one month after the surgery. Measured values of uric acid in patients with colorectal cancer were highest on the 1st day after the surgery (p=0.004), while there were no significant differences between values measured on the 7th day and one month after the surgery compared with preoperative uric acid values. Conclusion: Our results implicated that colorectal carcinoma was associated with systemic oxidative stress supporting a concept of cancer as systemic disorder manifested also as persistent oxidative stress. Moreover, in early postoperative period radical surgery induced acute phase response and changes in systemic oxidative stress markers as result of systemic stress response after surgical injury. In later postoperative period it was observed that activity of antioxidant system increased which might be related to tumor removal.

Oxidative stress; Colorectal cancer; Reactive oxygen species

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