Mixed papillary and medullary thyroid carcinoma (CROSBI ID 532078)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Moslavac, Sandra ; Marleku, Frane ; Janušić, Renato ; Gašparov, Slavko ; Knežević Obad, Anka ; Kardum-Skelin, Ika
engleski
Mixed papillary and medullary thyroid carcinoma
Mixed Papillary and Medullary Thyroid Carcinoma: A Case Report Mixed medullarypapillary thyroid carcinomas are rare tumors. On routine examination, a 50- year- old woman was found to have a thyroid nodule. Ultrasound (US) reveald a bilobate gland of normal size, with a nodule 10 mm in greatest diameter in the lower part of the right lobe. Hormone analysis showed euthyroidism. The routine percutaneous US- guided fine-needle aspiration (FNA) was performed using 22- gauge needle. The aspirate was smeared and stained routinely. The FNA showed abundant cellularity with follicular and papillary structures. In addition, other population of tumor cells were pleomorphic, large, with occasional binucleation and multinucleation, coarse chromatin and prominent nucleoli in clusters and singly. The intranuclear cytoplasmic invaginations were found in some cells. The cytological diagnosis of the dedifferentiated carcinoma was made and surgical treatment was recommended. The hystological diagnosis was mixed papillary and medullary carcinoma based on immunohystochemical analysis. The pleomorphic cells were calcitonin, TTF – 1, CEA, chromogranin synaptophisin and Ca 19, 9 positive. The cells with INCI („ ground glass“ nuclei) were thyreoglobulin positive. The presence of both medullary and papillary components is rare and may suggest that the tumor had arisen from a common stem cell. A case of mixed medullary, papillary, follicular and undifferentiated pattern of thyroid carcinoma also has been reported.
mixed papillary and medullary thyroid carcinoma ; dedifferentiated carcinoma ; immunohystochemical analysis ; fine-needle aspiration
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Podaci o prilogu
117-117.
2007.
objavljeno
Podaci o matičnoj publikaciji
Abstract Book
Santamaria, Mercedes
Madrid: Universidad del Pais Vasco
978-84-9860-001-8
Podaci o skupu
33rd European Congress of Cytology
poster
14.10.2007-17.10.2007
Madrid, Španjolska