engleski

Microbiological Surveillance of the surgical Intensive care unit in Zagreb- a pivot for Guidelines based Therapy of severe sepsis

The aim of this retrospective study was to create guidelines for therapy of sepsis in surgical intensive care unit (ICU) for unknown causative agent based on antimicrobial susceptibility of causative bacteria. Thirty-two patients with severe sepsis from surgical ICU in 2005. were included in study. Their clinical and microbiological data were analysed from the medical records. Antimicrobial susceptibility of the strains isolated from the blood-culture was tested by disk diffusion method according to NCCLS. APACHE II score was used to predict the severity of illness. Statistical significance difference between results was tested by Mann-Whitney test and x2 test. A.baumannii and P. aeruginosa were the predominant causative agent, displaying excellent susceptibility to ceftazidime, gentamicin and carbapenems. Methicillin-resistant Staphylococcus aureus (MRSA), third predominant causative agent exhibiting good susceptibility to vancomycin and linezolide. The recommended therapy is empirical and should cover all important pathogens.

severe sepsis; intensive care unit; empirical antibiotic therapy

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