engleski

Evaluation of Biological Distances in Patients Suffering from Extringic Asthma and Control population group

The question of pathogenesis of bronchial asthma. especially of extrinsic type has not been clarified. The IgE antibodies have a central role in the mechanism by which environment antigens cause allergic disease. In this study we analysed frequencies of dermatoglyphic patterns on fingers and palms of 100 patients suffering from extrinsic asthma (IgE higher than 800kU/l) and four different control populations in Croatia (Capital of Zagreb, village Selca - Island of Brač - village of stone miners, village Žrnovo - island of Korčula and village Potomje - Pelješac Peninsula). Three diagrams from the Hiernaux Dg biological distances show separate clusters for qualitative dermatoglyphic traits between male and female patients suffering from asthma and control groups, especially with those where most of population was and still is, exposed to stone dust. The conclusion from this analysis clearly indicate that differences found in dermatoglyphics, as polygenetically determined traits, between asthmatic patients and control groups could be caused by genetic predisposition of extrinsic asthma, but there is also possibility of environmental influence during intrauterine development. That means that during the early embryogenesis and morphogenesis, same factors influence the mutual embryological origin of dermatoglyphs and also the respiratory system.

extrinzic asthma; stone dust; dermatoglyphs; anthropology; population genetics

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