engleski

Ethiopathogenesis of Bronchopulmonary Carcinoma in Croatia

The most frequent death causing cancer in males in Croatia is the bronchopulmonary carcinoma. In this study we analyzed dermatoglyphs in 416 male and 135 female patients suffering from lung cancer, and 200 male and 200 female healthy adults. The quantitative dermatoglyphic analyses on 18 variables show classification results of canonical discrimination between patients suffering from lung cancer and control groups - in males 79.87 % and in females 79.70% cases are correctly grouped. The qualitative analysis of dermatoglyphic patterns between different types of lung cancer also show existing differences whilst using the Hiernaux Dg biological distance. Despite the biological heterogeneity of these tumors, there is proof of their common determination in comparison to the control group. This suggests polygenetic origin of these diseases and their possible common genetic alternation. Biological differences found among different types of carcinoma indicate that, although these tumors have a common origin, their biological distances create a basis for the conclusion that different pathways of genetic alterations represent the source of diverse pathophysiology of these diseases. Our findings are confirmed by other methods as well, for example, by methods of molecular biology where different types of genetic markers could be detected in different carcinomas.

lung cancer; pathophysiology of lung; dermatoglyphs; population genetics; anthropology

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