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Pregled bibliografske jedinice broj: 315163

Succesfull use of activated recombinant factor VII in life-threatening bleeding after thoracic surgery


Majerić Kogler, Višnja; Slobodnjak, Zoran; Samaržija, Miroslav; Špiček Macan, Jasna; Karadža, Vjekoslav; Jakopović, Marko
Succesfull use of activated recombinant factor VII in life-threatening bleeding after thoracic surgery // Swiss medical weekly, 137 (2007), 27-28; 407-410 (međunarodna recenzija, članak, znanstveni)


Naslov
Succesfull use of activated recombinant factor VII in life-threatening bleeding after thoracic surgery

Autori
Majerić Kogler, Višnja ; Slobodnjak, Zoran ; Samaržija, Miroslav ; Špiček Macan, Jasna ; Karadža, Vjekoslav ; Jakopović, Marko

Izvornik
Swiss medical weekly (1424-7860) 137 (2007), 27-28; 407-410

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Recombinant factor VII; thoracic surgery

Sažetak
We present three patients in whom life-threatening haemorrhage following lung resection was successfully managed using activated recombinant factor VII (NovoSeven((R))). In one case, activated recombinant factor VII was the only therapy administered to manage bleeding, ani in the two remaining cases, activated recombinant factor VII was administered after patients failed to respond to conventional therapy. All patients demonstrated effective haemostasis and improved coagulation parameters as a result of treatment with activated recombinant factor VII. Our experience with the clinical use of rFVIIa suggests that this agent may provide effective hemostasis following lifethreatening postoperative bleeding after major thoracic surgery. Despite these favorable results, randomized, placebo controlled trials are needed to identify optimal treatment strategy, patient selection, and safety of treatment in patients with massive bleeding following major thoracic surgery.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Jasminka Pavelić, )
108-0000000-0008 - Utjecaj liječenja akutne boli na tijek i ishod liječenja kirurških bolesnika (Višnja Majerić-Kogler, )

Ustanove
Klinika za plućne bolesti "Jordanovac"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE