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The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer


Bobinac, Dragica; Marić, Ivana; Markić, Dean; Cvijanović, Olga; Španjol, Josip; Ćelić, Tanja; Fučkar, Željko
The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer // Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto (ur.).
New York: Springer, 2007. str. s61-s61 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer

Autori
Bobinac, Dragica ; Marić, Ivana ; Markić, Dean ; Cvijanović, Olga ; Španjol, Josip ; Ćelić, Tanja ; Fučkar, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto - New York : Springer, 2007, S61-s61

Skup
European Symposium on Calcified Tissues (34 ; 2007)

Mjesto i datum
Kopenhagen, Danska, 05.-09.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Bone morphogenetic protein-7; BMP-receptors; kidney; kidney cancer; immunohistochemistry

Sažetak
Bone morphogenetic protein-7 has an important role during fetal kidney development. In adult human kidney the expression was found in proximal tubule and glomerular podocytes. The function of BMP-7 in normal kidney is still unclear but the reviews revealed protective role of BMP-7 in acute and chronic kidney disease. BMP-7 is efficient as antifibrotic factor and is able to reverse epithelial-mesenchymal transformation. The aim of the study was to explore the expression of BMP-7 in human normal kidney and kidney cancer cells. Immunohistochemical staining with anti BMP-7, anti BMPR-IA, anti BMPR-IB and anti BMPR-II was performed. Slides were incubated with the primary antibodies overnight at 4°C in PBS. The expression of BMP-7 was found in epithelial cells of distal tubule. But the expression of related BMPs receptors was found in epithelial cells od fistal and proximal tubules. Among receptors BMPR-IB expression was very strong. In the tissue of kidney cancer the expression of BMP-7 was negative. In the borderline tissue of the kidney cancer the expression of BMP-7 was still present. In the kidney cancer cells the expression of BMPs receptors was present especially BMPR-IA and BMPR-IB while BMPR-II was less expressed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Dragica Bobinac, )
062-0620226-0208 - Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva (Željka Crnčević Orlić, )
062-0620226-0209 - Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva (Ivana Marić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE