Adamantane Amino and Hydroxy Acids: Incorporation Into Cyclic Peptides and Depsipeptides for the Formation of New Lipophilic Tubular Materials (CROSBI ID 760592)
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Podaci o odgovornosti
Basarić, Nikola
engleski
Adamantane Amino and Hydroxy Acids: Incorporation Into Cyclic Peptides and Depsipeptides for the Formation of New Lipophilic Tubular Materials
Synthesis of peptidomimetics has attracted considerable attention in the recent years, mainly because of biological activity of these molecules. A special interest in the chemistry of peptidomimetics has been directed towards synthesis of cyclic peptides and depsipeptides which contain unnatural amino acids. Besides biological activity, these compounds showed also extremely good properties in solid state, forming tubular structures or ion channels.1 Since these structures may find important applications in nanotechnology, synthesis of new derivatives is under intensive investigation. In the scope of our research on chemistry of polycyclic molecules, and their application as the versatile building blocks, we turned our attention to the synthesis of unnatural amino acids2 and hydroxyacids3 which incorporate adamantane subunits. Synthesis of four adamantane derivatives (1-4) and their incorporation into peptide and depside fragments, as well as cyclizations of these fragments into cyclic peptidomimetics will be discussed.
Unnatural amino acids; hydroxy acids; peptides; depsipeptides
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Podaci o izdanju
Central Salt and Marine Chemicals Research Institute, Bhavnagar (Gujarat), India
2007.
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