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SAR and QSAR of the Antioxidant Activity of Flavonoids

Amić, Dragan; Davidović-Amić, Dušanka; Bešlo, Drago; Rastija, Vesna; Lučić, Bono; Trinajstić, Nenad
SAR and QSAR of the Antioxidant Activity of Flavonoids // Current Medicinal Chemistry, 14 (2007), 7; 827-845 (međunarodna recenzija, pregledni rad, znanstveni)

SAR and QSAR of the Antioxidant Activity of Flavonoids

Amić, Dragan ; Davidović-Amić, Dušanka ; Bešlo, Drago ; Rastija, Vesna ; Lučić, Bono ; Trinajstić, Nenad

Current Medicinal Chemistry (0929-8673) 14 (2007), 7; 827-845

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
SAR; QSAR; flavonoids; antioxidant activity; free radical scavenging; metal chelation; enzyme inhibition; prooxidant

Flavonoids are a group of naturally occurring phytochemicals abundantly present in fruits, vegetables, and beverages such as wine and tea. In the past two decades, flavonoids have gained enormous interest because of their beneficial health effects such as anti-inflammatory, cardio-protective and anticancer activities. These findings have contributed to the dramatic increase in the consumption and use of dietary supplements containing high concentrations of plant flavonoids. The pharmacological effect of flavonoids is mainly due to their antioxidant activity and their inhibition of certain enzymes. In spite of abundant data, structural requirements and mechanisms underlying these effects have not been fully understood. This review presents the current knowledge about structure-activity relationships (SARs) and quantitative structure-activity relationships (QSARs) of the antioxidant activity of flavonoids. SAR and QSAR can provide useful tools for revealing the nature of flavonoid antioxidant action. They may help in the design of new and efficient flavonoids, which could be used as potential therapeutic agents.

Izvorni jezik

Znanstvena područja


Projekt / tema
098-1770495-2919 - Razvoj metoda za modeliranje svojstava bioaktivnih molekula i proteina (Bono Lučić, )

Institut "Ruđer Bošković", Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus