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Pregled bibliografske jedinice broj: 313995

In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains


Drenjančević, Domagoj; Vraneš, Jasmina; Bedenić, Branka; Šakić-Zdravčević, Katarina
In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains // Collegium Anropologicum, 31 (2007), 1; 221-225 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 313995 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains

Autori
Drenjančević, Domagoj ; Vraneš, Jasmina ; Bedenić, Branka ; Šakić-Zdravčević, Katarina

Izvornik
Collegium Anropologicum (0350-6134) 31 (2007), 1; 221-225

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pseudomonas aeruginosa; antibiotics; subminimal inhibitory concentrations; serum bactericidal activity

Sažetak
The aim of this study was to determine the effect of subminimal inhibitory concentrations (subMICs) of ceftazidime, meropenem and gentamicin on the in vitro serum sensitivity of Pseudomonas aeruginosa strains isolated from a variety of isolation sites at two medical wards and an intensive care unit in a government university hospital in Croatia. A total of 20 serum-resistant P. aeruginosa strains isolated from different clinical specimens were selected. Bacteria were exposed to 1/2, 1/4, 1/8, 1/16, and 1/32 x MIC of each antibiotic tested. Sensitivity of P. aeruginosa strains to bactericidal activity of normal human serum before and after bacterial exposure to subMICs was determined. Significant difference in serum sensitivity of the strains was observed after the bacteria were exposed to subMICs of ceftazidime and meropenem (p<0.01), while the exposure to subMICs of gentamicin did not affect significantly the resistance of tested strains to the serum bactericidal activity. Comparing the number of serum-resistant strains before and after exposure to subMICs of antibiotics, statistically significant differences were determined (p<0.01) after exposure of the strains to 1/2, 1/4, 1/8 and 1/16 x MIC of meropenem, and after exposure to 1/2, 1/4 and 1/8 x MIC of ceftazidime. SubMICs of ceftazidime and meropenem affected not only the resistance to serum bactericidal activity of bacteria, but also their morphology. The alterations in bacterial morphology caused by subMICs of ceftazidime and meropenem could be connected with consecutive bacterial serum sensitivity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-3433 - Imunosni odgovor na kirurški stres u regionalnoj i općoj anesteziji (Šakić, Kata, MZOS ) ( POIROT)
108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( POIROT)
121-1080114-0306 - Djelovanje antibiotika na uzročnike biofilm infekcija (Vraneš, Jasmina, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada Hrčak

Citiraj ovu publikaciju:

Drenjančević, Domagoj; Vraneš, Jasmina; Bedenić, Branka; Šakić-Zdravčević, Katarina
In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains // Collegium Anropologicum, 31 (2007), 1; 221-225 (međunarodna recenzija, članak, znanstveni)
Drenjančević, D., Vraneš, J., Bedenić, B. & Šakić-Zdravčević, K. (2007) In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains. Collegium Anropologicum, 31 (1), 221-225.
@article{article, year = {2007}, pages = {221-225}, keywords = {Pseudomonas aeruginosa, antibiotics, subminimal inhibitory concentrations, serum bactericidal activity}, journal = {Collegium Anropologicum}, volume = {31}, number = {1}, issn = {0350-6134}, title = {In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains}, keyword = {Pseudomonas aeruginosa, antibiotics, subminimal inhibitory concentrations, serum bactericidal activity} }
@article{article, year = {2007}, pages = {221-225}, keywords = {Pseudomonas aeruginosa, antibiotics, subminimal inhibitory concentrations, serum bactericidal activity}, journal = {Collegium Anropologicum}, volume = {31}, number = {1}, issn = {0350-6134}, title = {In Vitro Effect of Subinhibitory Concentrations of Ceftazidime and Meropenem on the Serum Sensitivity of Pseudomonas aeruginosa Strains}, keyword = {Pseudomonas aeruginosa, antibiotics, subminimal inhibitory concentrations, serum bactericidal activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Social Sciences Index





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