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Pregled bibliografske jedinice broj: 313942

Reproductive toxicity of low-level lead exposure in men


Telišman, Spomenka; Čolak, Božo; Pizent, Alica; Jurasović, Jasna; Cvitković, Petar
Reproductive toxicity of low-level lead exposure in men // Environmental Research, 105 (2007), 256-266 (međunarodna recenzija, članak, znanstveni)


Naslov
Reproductive toxicity of low-level lead exposure in men

Autori
Telišman, Spomenka ; Čolak, Božo ; Pizent, Alica ; Jurasović, Jasna ; Cvitković, Petar

Izvornik
Environmental Research (0013-9351) 105 (2007); 256-266

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human semen quality; sex hormones; prostate damage; nonoccupational lead exposure; toxic and essential metals interaction

Sažetak
Parameters of semen quality, seminal plasma indicators of secretory function of the prostate and seminal vesicles, sex hormones in serum, and biomarkers of lead, cadmium, copper, zinc, and selenium body burden were measured in 240 Croatian men 19-52 years of age. The subjects had no occupational exposure to metals and no known other reasons suspected of influencing male reproductive function or metal metabolism. After adjusting for age, smoking, alcohol, blood cadmium, and serum copper, zinc, and selenium by multiple regression, significant (P < 0.05) associations of blood lead (BPb), &#948; -aminolevulinic acid dehydratase (ALAD), and/or erythrocyte protoporphyrin (EP) with reproductive parameters indicated a lead-related increase in immature sperm concentration, in percentages of pathologic sperm, wide sperm, round sperm, and short sperm, in serum levels of testosterone and estradiol, and a decrease in seminal plasma zinc and in serum prolactin. These reproductive effects were observed at low-level lead exposure (BPb median 49 &micro ; g/L, range 11-149 &micro ; g/L in the 240 subjects) common for general populations worldwide. The observed significant synergistic effect of BPb and blood cadmium on increasing serum testosterone, and additive effect of a decrease in serum selenium on increasing serum testosterone, may have implications on the initiation and development of prostate cancer because testosterone augments the progress of prostate cancer in its early stages.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
022-0222411-2408 - Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca (Alica Pizent, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE