engleski

Immunological reactivity in elderly patients with chronic lymphocytic leukemia (CLL)

Chronic lymphocytic leukemia (CLL) is a disease of elderly people. As elderly people in general have impaired humoral and cellular immunity, we compared cellular markers and immune functions of CLL patients (60-87 years of age) with age matched controls as well as with younger controls (20-60 years). T lymphocytes and NK activity were decreased while digestion function of phagocytes was increased in patients as compared to the age matched controls. If compared to younger controls, both T and B lymphocytes, NK activity and phagocytic functions (ingestion and ADCC) were impaired. Because this discrepances, due to age, it is necessary to deal with age-matched controls.

lymphocyte subpopulations ; rosette teshniques ; NK activity ; phagocytosis ; ADCC ; digestion ; random mobility

nije evidentirano