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Pregled bibliografske jedinice broj: 312481

Analysis of one million base pairs of Neanderthal DNA


Green, Richard E.; Krause, Johannes; Ptak, Susan E.; Briggs, Adrian W.; Ronan, Michael T.; Simons, Jan F.; Du, Lei; Egholm, Michael; Rothberg, Jonathan M.; Paunović, Maja; Paabo, Svante
Analysis of one million base pairs of Neanderthal DNA // Nature, 444 (2006), 330-336 (međunarodna recenzija, članak, znanstveni)


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Naslov
Analysis of one million base pairs of Neanderthal DNA

Autori
Green, Richard E. ; Krause, Johannes ; Ptak, Susan E. ; Briggs, Adrian W. ; Ronan, Michael T. ; Simons, Jan F. ; Du, Lei ; Egholm, Michael ; Rothberg, Jonathan M. ; Paunović, Maja ; Paabo, Svante

Izvornik
Nature (0028-0836) 444 (2006); 330-336

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Neanderthal DNA; genome sequence

Sažetak
Neanderthals are the extinct hominid group most closely related to contemporary human, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38, 000-year-old Neandethal fossil that is exceptionally free of contamination from modern human DNA. Direct high-throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500, 000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort.

Izvorni jezik
Engleski

Znanstvena područja
Geologija



POVEZANOST RADA


Projekti:
0101018

Ustanove:
Hrvatska akademija znanosti i umjetnosti


Citiraj ovu publikaciju

Green, Richard E.; Krause, Johannes; Ptak, Susan E.; Briggs, Adrian W.; Ronan, Michael T.; Simons, Jan F.; Du, Lei; Egholm, Michael; Rothberg, Jonathan M.; Paunović, Maja; Paabo, Svante
Analysis of one million base pairs of Neanderthal DNA // Nature, 444 (2006), 330-336 (međunarodna recenzija, članak, znanstveni)
Green, R., Krause, J., Ptak, S., Briggs, A., Ronan, M., Simons, J., Du, L., Egholm, M., Rothberg, J., Paunović, M. & Paabo, S. (2006) Analysis of one million base pairs of Neanderthal DNA. Nature, 444, 330-336.
@article{article, year = {2006}, pages = {330-336}, keywords = {Neanderthal DNA, genome sequence}, journal = {Nature}, volume = {444}, issn = {0028-0836}, title = {Analysis of one million base pairs of Neanderthal DNA}, keyword = {Neanderthal DNA, genome sequence} }
@article{article, year = {2006}, pages = {330-336}, keywords = {Neanderthal DNA, genome sequence}, journal = {Nature}, volume = {444}, issn = {0028-0836}, title = {Analysis of one million base pairs of Neanderthal DNA}, keyword = {Neanderthal DNA, genome sequence} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE





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