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Development of T lymphocytes at extrathymic sites (CROSBI ID 84395)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Antica, Mariastefania ; Scollay, Roland Development of T lymphocytes at extrathymic sites // Journal of immunology, 163 (1999), 1; 206-211

Podaci o odgovornosti

Antica, Mariastefania ; Scollay, Roland

engleski

Development of T lymphocytes at extrathymic sites

Unique Identifier 99316305 T lymphocytes expressing both CD4 and CD8 are the predominant cell type in the thymic cortex but are extremely rare outside the thymus of normal mice. In this article, we show that if precursor thymocytes (CD4-CD8-) from fetal or adult donors are injected i.v. into irradiated recipients, some of these cells will lodge in lymph nodes and develop into both CD4+CD8+ (double-positive) and CD4+ or CD8+ (single-positive) cells. This phenomenon also occurred in thymectomized recipients, strongly suggesting it is genuine extrathymic development. Prethymic precursors (e.g., fetal liver), were unable to use the lymph node for T cell development, without thymic processing. The data suggest that given unusual circumstances (irradiation or thymectomy and availability of appropriate precursors), the lymph nodes can support T cell development.

T lymphocytes ; development ; double positive thymocytes

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Podaci o izdanju

163 (1)

1999.

206-211

objavljeno

0022-1767

1550-6606

Povezanost rada

Kliničke medicinske znanosti

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