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Pregled bibliografske jedinice broj: 31218

Development of T lymphocytes at extrathymic sites


Antica, Mariastefania; Scollay, Roland
Development of T lymphocytes at extrathymic sites // Journal of immunology, 163 (1999), 1; 206-211 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 31218 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Development of T lymphocytes at extrathymic sites

Autori
Antica, Mariastefania ; Scollay, Roland

Izvornik
Journal of immunology (0022-1767) 163 (1999), 1; 206-211

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
T lymphocytes ; development ; double positive thymocytes

Sažetak
Unique Identifier 99316305 T lymphocytes expressing both CD4 and CD8 are the predominant cell type in the thymic cortex but are extremely rare outside the thymus of normal mice. In this article, we show that if precursor thymocytes (CD4-CD8-) from fetal or adult donors are injected i.v. into irradiated recipients, some of these cells will lodge in lymph nodes and develop into both CD4+CD8+ (double-positive) and CD4+ or CD8+ (single-positive) cells. This phenomenon also occurred in thymectomized recipients, strongly suggesting it is genuine extrathymic development. Prethymic precursors (e.g., fetal liver), were unable to use the lymph node for T cell development, without thymic processing. The data suggest that given unusual circumstances (irradiation or thymectomy and availability of appropriate precursors), the lymph nodes can support T cell development.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
00981101

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Citiraj ovu publikaciju

Antica, Mariastefania; Scollay, Roland
Development of T lymphocytes at extrathymic sites // Journal of immunology, 163 (1999), 1; 206-211 (međunarodna recenzija, članak, znanstveni)
Antica, M. & Scollay, R. (1999) Development of T lymphocytes at extrathymic sites. Journal of immunology, 163 (1), 206-211.
@article{article, year = {1999}, pages = {206-211}, keywords = {T lymphocytes, development, double positive thymocytes}, journal = {Journal of immunology}, volume = {163}, number = {1}, issn = {0022-1767}, title = {Development of T lymphocytes at extrathymic sites}, keyword = {T lymphocytes, development, double positive thymocytes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE