engleski

HPV type distribution in invasive cervical cancer: the worldwide perspective

Objective: To describe the HPV genotype distribution in invasive cervical cancer worldwide. Methods: Paraffin embedded cervical cancer cases were collected from historical archives (1920-2005). HPV detection was done through amplification of HPV DNA by SPF-10 broad-spectrum primers PCR subsequently followed by DEIA and genotyping by LiPA25 (version 1). Samples were tested at HPV laboratories at ICO (Barcelona, Spain) and at DDL (The Netherlands). Quality controls between the two labs are occurring regularly. Results presented here originate from samples collected in Algeria, Argentina, Australia, Bosnia-Herzegovina, Brazil, Chile, China, Colombia, Croatia, Czech Republic, France, Honduras, Italy, Japan, Korea S, Mexico, Mozambique, Netherlands, Nigeria, Paraguay, Peru, Portugal, Spain, Thailand, Turkey, Uganda, and USA. Samples from Bangladesh, Guatemala, India, Philippines, Taiwan and Venezuela are being tested. Results:13, 239 women were included in the study. Of these, 11, 171 have now been evaluated histologically and 9, 760 were considered suitable for testing. HPV genotype data are available for 8, 785 cases on cervical cancer. The five most common types detected after LIPA were HPV 16 (60.3%), HPV 18 (10.3%), HPV 45 (5.9%), HPV 31 (4.2%) and HPV 33 (4.0%). This distribution was consistent across continents with the exception of Asia where HPV 58 ranked 3rd and in Oceania where HPV 68/73 ranked 4th. HPV 16 and 18 accounted for 70.3% (range by continent= 66.0%-78.4%). This pattern was greatly dominated by squamous carcinomas. Among adenocarcinomas (10% of all tumours), HPV 16 accounted for 47.8% (range by continent= 35.5%-53.2%) and HPV 18 for 29.0% (range by continent= 23.5%-36.9%). Presence of exclusively low risk types accounted for 0.44% of all cases. Multiple infections were detected in 4.8% of the samples. Discussion: HPV 16 and 18 are the most common HPV types in cervical cancer cases around the world.

Human papillomaviruses (HPV)

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