engleski

Psychosocial factors contributing to the persistence of depression in type 2 diabetic patients: A Croatian survey from the European Depression in Diabetes Research Consortium

Objective: The study was aimed at exploring a one-year course of depression in persons with type 2 diabetes and analysing demographic, disease-related and psychological variables that may predict depression persistence. Patients and methods: One hundred patients from a randomly selected sample of 470 outpatients were found to be suffering from severe depressive symptoms. They were followed and re-examined for depression after one year. Depression was assessed by the Center for Epidemiologic Studies-Depression scale, and a face-to-face diagnostic interview relying on the DSM-IV. Depression, health-related quality of life and diabetes-related distress were assessed at baseline. Non-parametric tests for between-group differences were used to compare patients who recovered from depression with those who still suffered from severe depressive symptoms. Multiple logistic regression was used to determine predictors of depression persistence. Results: Seventy-nine of 100 patients with baseline depression scores indicative of severe depression were reached at one-year follow-up. Among them, 53% were shown to have improved depressive symptoms, while 47% continued to suffer from severe depressive symptoms. Logistic regression analysis indicated that psychosocial variables were more strongly associated with persistent depression than demographic and diabetes-related ones. Baseline severity of depression, diabetes-related distress and subjectively perceived quality of life were shown to independently predict one-year depression outcomes (OR =3.5 /CI 1.17-10.71/ p=0.02 ; OR=3.5 /CI 1.2-10.5/ p=0.02 and OR=0.94 /CI 0.91-0.98/ respectively). Conclusions: Severity of baseline depression, a degree to which depression disrupted the affected patients' quality of life, and concomitant emotional problems related to diabetes were shown to be associated with persistent depresive disturbances.

depressive symptoms; type 2 diabetes; diabetes-related distress; quality of life; persistence of depression

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