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The mechanism of recurrence of mouse myeloid leukaemia after total body irradiation and bone marrow transplantation

Recurrent leukaemia was observed in lethaly iradiated mice reconstituted with singeneic or allogeneic bone marrow. Irradiated myeloid leukaemia (ML) cells in vitro, were also capable of causing leukemia if were inoculated into lethally irradiated mice reconstituted with bone marrow cells.That was attributed to the release of a leukaemogenic factor from the ML cells, capable transforming transplanted normal bine marrow cells.

leukaemia recurrence ; leukaemogenic factor ; bone marrow transplantation ; total body irradiation ; mice

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