engleski

Influence of iron on proliferation and cell cycle kinetics on cultured malignant and nonmalignant cell

The presence of an iron-containing complex (FSC, ferric sorbitol citrate) in medium inhibited proliferation of malignant(KB, GHC) cells ; but did not appreciably alter the proliferation of normal (HBS, Varo) cells. Flow cytometric analysis showed considerable differences of malignant and normal cell growth kinetics. Addition of 200 microM Fe in medium suppressed malignant cell proliferation. An increased number of cell in G1 and early S phase suggested that iron excess blocked the cell cycle before beginning of DNA synthesis.

iron ; cell cycle ; malignant cell

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