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Pregled bibliografske jedinice broj: 310886

I-131-induced changes in rat thyroid gland function


Torlak, Vesela; Zemunik, Tatijana; Modun, Darko; Čapkun, Vesna; Pešutić-Pisac, Valdi; Markotić, Anita; Pavela-Vrančić, Maja; Staničić, Ante
I-131-induced changes in rat thyroid gland function // Brazilian Journal of Medical & Biological Research, 40 (2007), 8; 1087-1094 (međunarodna recenzija, članak, znanstveni)


Naslov
I-131-induced changes in rat thyroid gland function

Autori
Torlak, Vesela ; Zemunik, Tatijana ; Modun, Darko ; Čapkun, Vesna ; Pešutić-Pisac, Valdi ; Markotić, Anita ; Pavela-Vrančić, Maja ; Staničić, Ante

Izvornik
Brazilian Journal of Medical & Biological Research (0100-879X) 40 (2007), 8; 1087-1094

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thyroid gland; 131I; hormones; histopathology; T3; T4; TSH

Sažetak
Therapeutic doses of (131)I administered to thyrotoxic patients may cause thyroid failure. The present study used a rat model to determine thyroid function after the administration of different doses of (131)I (64-277 microCi). Thirty male Fisher rats in the experimental group and 30 in the control group (untreated) were followed for 6 months. The animals were 4 months old at the beginning of the experiment and were sacrificed at an age of 9 months. Hormone concentration was determined before (131)I administration (4-month-old animals) and three times following (131)I administration, when the animals were 7, 8, and 9 months old. The thyroid glands were removed and weighed, their volume was determined and histopathological examination was performed at the end of the experiment. Significant differences in serum triiodothyronine and thyroid-stimulating hormone concentration, measured at the age of 7, 8, and 9 months, were found in the experimental group. During aging of the animals, the concentration of thyroxin fell from 64.8 +/- 8.16 to 55.0 +/- 6.1 nM in the control group and from 69.4 +/- 6.9 to 25.4 +/- 3.2 nM in the experimental group. Thyroid gland volume and weight were significantly lower in the experimental than in the control group. Thyroid glands from the experimental group showed hyaline thickness of the blood vessel wall, necrotic follicles, a strong inflammatory reaction, and peeling of necrotic cells in the follicles. In conclusion, significant differences in hormone levels and histopathological findings indicated prolonged hypothyroidism after (131)I administration to rats, which was not (131)I dose dependent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
177-0000000-2962 - Oligomerni enzimski sustavi u sintezi bioaktivnih sekundarnih metabolita (Maja Pavela-Vrančić, )
216-0000000-0085 - Kancerogeneza i prognostički biljezi kod pločastog karcinoma grkljana (Valdi Pešutić-Pisac, )
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Tatijana Zemunik, )
216-2160133-0066 - Patobiokemija glikosfingolipidnih antigena (Anita Markotić, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE