engleski

Genetics of cardiovascular disease

Several biochemical and environmental risk factors of cardiovascular disease are well established, but genetic risk alleles contributing to the disease in the general population are hotly debated. The reason for such interest in incorporating genetic research into study of atherosclerotic and thrombotic diseases of cardiovascular system, including myocardial infarction, stroke, peripheral vascular disease and venous thromboembolism, is awareness of the fact that these diseases are still the major public health problem and cause of death and morbidity. Over past five years public health agencies have begun to examine how advances in genetic research can be used to prevent disease and improve health of population. On the other side, dramatic strides in unraveling the environmental influences on classic complex cardiovascular disease have translated into major public health efforts to alter lifestyle and diet. Furthermore, the advances in cardiovascular genetics - basic research in the biology of lipid metabolism, have led to drugs that change the natural history of disease progression. Although the drop in death rates from cardiovascular disease represents one of the major victories for the twentieth-century medicine, the prevalence of disease remains high, especially in CEE and SEE countries. Classical epidemiologic studies have validated a set of criteria that are widely employed in evaluation and management of patients at risk for cardiovascular disorders. The lessons learned from risk assessment of biochemical markers for atherosclerosis are expected to be important in developing strategy to integrate genetics into public health policies and national strategy for prevention of cardiovascular disease. A framework for applying human genome research to disease prevention includes genetic epidemiology ; development of screening of target populations, ethical, socioeconomic and legal implications, training and education of professionals and public.

Risk factors ; Cardiovascular disease ; Alleles ; Myocardial infarction ; Stroke ; Thromboembolism

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