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Soluble serum transferrin receptor and transferrin receptor-ferritin index in the assessment of the iron status in anemia of chronic kidney disease


Margetić, Sandra; Topić, Elizabeta; Tešija-Kuna, Andrea; Vukasović Ines
Soluble serum transferrin receptor and transferrin receptor-ferritin index in the assessment of the iron status in anemia of chronic kidney disease // Clinical Chemistry and Laboratory Medicine / Siest, Gerard (ur.).
Berlin: Walter de Gruyter, 2007. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Soluble serum transferrin receptor and transferrin receptor-ferritin index in the assessment of the iron status in anemia of chronic kidney disease

Autori
Margetić, Sandra ; Topić, Elizabeta ; Tešija-Kuna, Andrea ; Vukasović Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / Siest, Gerard - Berlin : Walter de Gruyter, 2007

Skup
17th European Congress of Clinical Chemistry and Laboratory Medicine, Euromedlab 2007

Mjesto i datum
Amsterdam, Nizozemska, 4.-7.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Soluble serum transferrin receptor; Transferrin receptor-ferritin index; Anemia of chronic kidney disease

Sažetak
Objective. The aim of this study was to assess the value of the soluble serum trensferrin receptor (sTfR) and the transferrin receptor-ferritin index (sTfR/logF) as newmarkers of iron ststus in patients with anemia of chronic kidney disease (ACKD) both treated and not treated with recombinant human erythropoietin (rHuEPO) therapy. Materials and Methods. The study included 53 patients and 61 controls. The concentration of sTfR was determined by an immunoturbidimetric assay. Values for the sTfR/logF index were calculated as the ratio of sTfR to logarithm ferritin level. Results. The results showed iron-depleted patients had significantly higher median sTfR/logF values (sTfR: 1.75 and 1.40 mg/L ; sTfR/logF: 0.99 and 0.77) relative to those of iron-repleted patients (sTfR: 1.07 and 0.73 mg/L ; sTfR/logF: 0.39 and 0.26) in ACKD patients-both those not treated with rHuEPO. Receiver operating characteristic analysis showed a higher diagnostic accuracy of the sTfR/logF index (area under curve (AUC) = 0.970) versus sTfR concentration (AUC=0.890) in the assessment of the iron status of ACKD patients. The etested parameters showed no significant differences according to C-reactive protein concentration (p=0.108 and 0.147), in contrast to serum ferritin concentration (p=0.045). Conclusions: The study results showed the tested parameters to be reliable in the assessement of the iron status of patients with ACKD, with a higher discriminating power of the sTfR/logF index versus the sTfR. It is expected that combined measurements of ferritin and sTfR concentrations with sTfR/logF index calculation could improve diagnostic reliability for accurate evaluation of the iron status of patients with ACKD, particulary those with concomitant inflammatory or infective conditions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-0061245-0205 - Hemoreološki poremećaji u kroničnim bolestima (Nada Vrkić, )
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Ana-Maria Šimundić, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE