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Pregled bibliografske jedinice broj: 309204

Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women


Milutin Gašperov, Nina; Sabol, Ivan; Halec, Gordana; Matovina, Mihaela; Grce, Magdalena
Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women // Collegium Antropologicum, 31 (2007), Suppl. 2; 89-96 (međunarodna recenzija, članak, znanstveni)


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Naslov
Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women

Autori
Milutin Gašperov, Nina ; Sabol, Ivan ; Halec, Gordana ; Matovina, Mihaela ; Grce, Magdalena

Izvornik
Collegium Antropologicum (0350-6134) 31 (2007), Suppl. 2; 89-96

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human papillomavirus (HPV) ; high-risk (HR) types ; Croatia

Sažetak
The infection with human papillomavirus (HPV) is the necessary cause for cervical cancer. There are at least 15 high-risk (HR) HPV types that are significantly associated with progression of cervical intraepithelial neoplasia to cervical cancer. Since previous studies showed that the prevalence of HPV in cervical cancers varies among different geographic regions, we wanted to investigate the prevalence of HPV types in Croatia, especially low abundant HR HPV types. By means of consensus primers directed polymerase chain reaction (PCR), we analysed cervical DNA samples of 2, 136 Croatian women, mostly with abnormal cervical smears, in order to detect the presence of HPV. Type-specific primers were then used to determine low-risk (LR) HPV types 6/11 and HR HPV types 16, 18, 31, 33, 45, 52 and 58. Out of 2, 136 specimens, 1, 255 (58.8%) were positive for HPV. More than half of positive samples were typed (64.5%) and 35.5% still remained untyped. Multiple HPV infections were found in 10.3% of the cases. The most prevalent type, including both single and multiple infections, was HPV 16 with the prevalence of 15.9%, followed by HPV types 31, 6/11, 33, 18, 52, 45 and 58 with 8.7%, 7.1%, 4.5%, 3.8%, 2.3%, 1.2% and 1.1%, respectively. The significant increase of frequency from low-grade squamous intraepithelial lesions (LSIL) to high-grade squamous intraepithelial lesions (HSIL) was observed for HR HPV types 16, 18, 31 and 33 but not 45, 52 and 58. The frequency of unknown HPV types was almost the same in cervical specimens of women with LSIL and those with HSIL, 19.8% and 21.1%, respectively. The prevalence of HPV infection rate decreased significantly with patient age from 68.5% (age group 12 to 24 years) to 38.8% (age group 45 to 54 years). But, in women aged 55 or older the overall prevalence increased to 56.6%. Our results indicate that prevalence of HR HPV types in Croatia is similar to other countries. We suggest that HPV positive women in Croatia should be closely monitored by typing for HR HPV types: 16, 18, 31, 33, 45, 52 and 58.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2510 - Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima (Magdalena Grce, )
101-0982464-2277 - Molekularno profiliranje metastazirajućeg tumora dojke (Dragan Dekaris, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Milutin Gašperov, Nina; Sabol, Ivan; Halec, Gordana; Matovina, Mihaela; Grce, Magdalena
Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women // Collegium Antropologicum, 31 (2007), Suppl. 2; 89-96 (međunarodna recenzija, članak, znanstveni)
Milutin Gašperov, N., Sabol, I., Halec, G., Matovina, M. & Grce, M. (2007) Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women. Collegium Antropologicum, 31 (Suppl. 2), 89-96.
@article{article, year = {2007}, pages = {89-96}, keywords = {human papillomavirus (HPV), high-risk (HR) types, Croatia}, journal = {Collegium Antropologicum}, volume = {31}, number = {Suppl. 2}, issn = {0350-6134}, title = {Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women}, keyword = {human papillomavirus (HPV), high-risk (HR) types, Croatia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE