Detection of minimal residual disease in acute promyelocytic leukemia by polymerase chain reaction assay for PML/RARalpha (retinoic acid receptor-alpha) fusion transcript. (CROSBI ID 470852)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Nemet, Damir ; Grahovac, Blaženka ; Labar, Boris ; Mrsić, Mirando ; Bogdanić, Vinko ; Hitrec, Vlasta ; Zaher, Dunja ; Zadro, Renata ; Boban, Dubravka
engleski
Detection of minimal residual disease in acute promyelocytic leukemia by polymerase chain reaction assay for PML/RARalpha (retinoic acid receptor-alpha) fusion transcript.
Seven patients with acute promyelocytic leukemia (APL)treated with all-trans retinoic acid (ATRA) for remission (CR) induction and with chemotherapy (CT) for consolidation of CR underwent residual disease monitoring through reverse transcription polymerase chain reaction (PCR) for PML/retinoic acid receptor alpha (PML/RAR alpha) fusion transcript. In six patients PCR was positive immediately after ATRA induced CR and/or after the first CT course.Two patients became PCR negative following repeated courses of CT and they are in remission 7 and 14 months, respectively. Four other patients relapsed. This pilot study indicates that PCR for PML/RAR alpha is very sensitive assay for detection of residual disease in APL.
acute promyelocytic leukemia; PML/RAR alpha; PCR assay; all-trans retinoic acid
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Podaci o prilogu
149-153-x.
1996.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Molecular Oncology Today
Osmak, Maja ; Škrk, Janez
Zagreb: Croatian Ligue Against Cancer
Podaci o skupu
Nepoznat skup
pozvano predavanje
29.02.1904-29.02.2096