engleski

Cardioprotective effects of 2, 3-butanendione monoxime against the vipera ammodytes ammodytes venom in the isolated rat heart

The nose-horned viper, Vipera ammodytes ammodytes, the most venomous snake in Europe is widespread in its southeastern part, including Croatia. The venoms of Viperinae family cause local tissue damage and systemic symptoms, including cardio circulatory disturbances. The aim of this study was to examine the cardioprotective effects of 2, 3-butanendione monoxime (BDM), a potent negative inotropic and vasodilatatory agent that causes excitation-contraction uncoupling in muscles. The effects of BDM were compared with effects of cyclooxygenase inhibitor (indomethacin), lipoxygenase inhibitor (nordihydroguaiaretic acid (NDGA)), inhibitor cytochrome P450 enzymes (clotrimazole), L-type Ca2+ channels blocker (verapamil) and phospholipase A2 inhibitor (quinacrine), agents that have been shown to have cardioprotective effects against different snake venoms. Under in vitro conditions BDM proved to be very effective protector against cardio toxic effects of the nose-horned viper venom. Further studies under in vivo conditions are warranted.

Cardioprotection; Venom; Snake; BDM; Isolated Heart

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