Cardioprotective effects of 2, 3-butanendione monoxime against the vipera ammodytes ammodytes venom in the isolated rat heart (CROSBI ID 529966)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Brizić, Ivica ; Lukšić, Boris ; Modun, Darko ; Vuković, Jonatan ; Musić, Ivana ; Boban, Mladen
engleski
Cardioprotective effects of 2, 3-butanendione monoxime against the vipera ammodytes ammodytes venom in the isolated rat heart
The nose-horned viper, Vipera ammodytes ammodytes, the most venomous snake in Europe is widespread in its southeastern part, including Croatia. The venoms of Viperinae family cause local tissue damage and systemic symptoms, including cardio circulatory disturbances. The aim of this study was to examine the cardioprotective effects of 2, 3-butanendione monoxime (BDM), a potent negative inotropic and vasodilatatory agent that causes excitation-contraction uncoupling in muscles. The effects of BDM were compared with effects of cyclooxygenase inhibitor (indomethacin), lipoxygenase inhibitor (nordihydroguaiaretic acid (NDGA)), inhibitor cytochrome P450 enzymes (clotrimazole), L-type Ca2+ channels blocker (verapamil) and phospholipase A2 inhibitor (quinacrine), agents that have been shown to have cardioprotective effects against different snake venoms. Under in vitro conditions BDM proved to be very effective protector against cardio toxic effects of the nose-horned viper venom. Further studies under in vivo conditions are warranted.
Cardioprotection; Venom; Snake; BDM; Isolated Heart
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Podaci o prilogu
110-x.
2007.
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objavljeno
Podaci o matičnoj publikaciji
Periodicum biologorum
Vitale, Branko
Zagreb: Hrvatsko prirodoslovno društvo
0031-5362
Podaci o skupu
5th croatian congress of pharmacology and 2nd congress of croatian physiological society
poster
19.09.2007-22.09.2007
Osijek, Hrvatska
Povezanost rada
Temeljne medicinske znanosti