engleski

C-reactive protein gene polymorphisms as predictors of cardiovascular disease

Background. C-reactive protein (CRP) is a good predictor of cardiovascular events. Human CRP gene polymorphisms may have an influence on development of coronary artery disease (CAD) and may alter the concentration of CRP in serum. Methods. PCR-RFLP methods were used for genotyping of CRP -717A/G and 1059G/C CRP-gene polymorphisms in patients with (+) and without (-) angiographically confirmed CAD. Serum concentrations of CRP were determined by immunoturbidimetry. Results. Absolute frequencies of CRP 1059G/C gene variants were significantly different between CAD+ and CAD- subjects. Wild type GG genotype and genotypes GC+CC with rare allele were 184 and 22 in CAD+ group, and 101 and 24 in CAD- group, respectively. Pearson’ s Chi-square were 4.72, p=0.030 and odds ratio were 0.269 to 0.942, p=0.032. Median CRP-concentrations between GG and GC+CC were significantly different in CAD- group, p=0.033. Absolute frequencies of CRP -717A/G variants were not statistically different between groups studied. Wild type AA genotype and genotypes AG+AA with rare allele were155 and 85 in CAD+ group, and 83 and 49 in CAD- group, respectively. CRP concentrations were not significantly different between CRP -717A/G genotypes in both groups studied. Conclusions. CRP gene variants may be involved in pathophysiology of CAD. Higher frequency of rare 1059C allele in CAD-, as well as lower CRP concentrations in GC+CC genotype indicate a protective role of 1059C allele.

C-reactive protein (CRP); CRP gene polymorphisms; coronary artery disease

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