engleski

Mitochondrial DNA Haplogroup Diversity of the Island of Vis

The aim of this study was to determine population genetic structure of the mitochondrial haplogroups in an isolated island population as well as the overall level of genetic diversity. MtDNA variation was explored in a sample of 130 individuals from the Island of Vis (eastern Adriatic) by sequencing HVS-I region between nps 16024 and 16383 and screening of selected RFLP sites diagnostic for main Eurasian mtDNA haplogroups. Similar to other European populations, the most frequent mtDNA haplogroups were H (30.0%) and U (26.15%). However, as in other previously investigated Croatian islands, the Island of Vis shows departures of certain (sub) haplogroups from the expected frequencies implying to genetic drift: the increased frequency of haplogroup HV (9.23%), subhaplogroup U5 (22.3%) and preV (3.85%) ; absence of haplogroup I and decreased frequency of haplogroup J (4.62%). Furthermore, the frequencies of haplogroups V and T are increased comparing to general Croatian sample. The phylogenetic analysis of haplogroups showed relatively high number of haplotypes in some haplogroups (H and U) that confirm their heterogeneity and their early age ancestry. On the other side, homogenity of haplotypes in some haplogroups (HV) confirms the effect of genetic drift in a small and isolated population. As in other Croatian islands the genetic drift caused by founder effect has been the main evolutionary force included in shaping the observed genetic diversity of mtDNA on the Island of Vis.

isolated population; mitochondrial DNA; Island of Vis; genetic drift

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