engleski

Transdifferentiation of retinal cells: a possible mechanism of lentoidogenesis in human teratomas.

Cells of the ocular lens differentiate from the surface ectoderm. However, in rat experimental teratomas originating from gastrulating embryos transferred to ectopic sites (under the kidney capsule or in vitro) they probably develop from neural retina cells by the process of transdifferentiation (metaplasia). Direct evidence of this process in humans was obtained in vitro. Only in one case of female newborn sacrococcygeal teratoma, cells of the ocular lens were found. The presence of masses of primitive neural retina cells surrounding lentoids, as well as the absence of epidermal structures in their vicinity, led us to the conclusion that in this case lentoids probably also developed by the process of transdifferentiation of neural retina cells.

transdifferentiation; retinal cells; lentiodogenesis; human teratomas

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