engleski

Intra- and intergenotype characterization of D6 measles virus genotype

Determination of inter- and intragenotype stability and variability is the basic tools for molecular epidemiology and evolutionary investigation of measles virus (MV). We made a comparison between complete genome sequences of four MVs (two wt and two SSPE MV strains), all belonging to genotype D6. Results of analyses clearly confirm that MV genome continuously change within the viruses of the same or different genotypes by accumulation of mutations in different parts of the genome. Only a small number of these accumulated mutations induce amino acid substitutions and thus probably introduces new biological characteristics or a new genotype for a long time period. This study clearly reveals a long untranslated region between M and F genes as the one of the most variable regions of the MV genome and detects the presence of unique residues on the level of entire genome as a new important parameter in the investigation of molecular evolution of MVs.

measles; genotype; epidemiology

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