Novel chloroenyne-modified amino acid derivatives (CROSBI ID 133492)
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Podaci o odgovornosti
Gredičak, Matija ; Kolonić, Anita ; Jerić, Ivanka
engleski
Novel chloroenyne-modified amino acid derivatives
Three groups of chloroenyne-modified amino acids were synthesized. Chloroenyne moiety was attached at the N- or C-terminal amino acid (Tyr, Phe, Val, Gly, Lys) position carrying different protecting groups. Prepared derivatives will be used as building blocks in the synthesis of enediyne-peptide conjugates. Furthermore, reactivity of modified amino acids in the peptide bond formation reaction was tested.
Amino acid modifications; Sonogashira reaction; Enediynes; Chloroenynes
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