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Enzyme Activity of Serum Dipeptidyl Peptidase IV (DPP IV/CD26) in Rheumatoid Arthritis

The dipeptidyl peptidase IV (DPP IV/CD26) is a multifunctional glycoprotein present both in a soluble form in many biological fluids and on the surface of different cells type. It could play an important role in the modulation of immune and inflammatory processes. A number of different proinflammatory peptides involved in rheumatoid arthritis pathogenesis, like RANTES and stromal cell-derived factor (SDF)-1a are substrates for DPP IV. The aim of this study was to assess the serum DPP IV activity in patients with rheumatoid arthritis, psoriatic arthritis, and osteoporosis, compared to healthy controls. Matherial and According to their clinical and laboratory data, patients were divided in three groups: patients with rheumatoid arthritis, psoriatic arthritis and patients with osteoporosis. The control group included 65 healthy blood donors. The serum DPP IV activity has been measured spectrofotometrically using Gly-Pro p-nitroanilide as substrate. A statistically significant decrease in serum DPP IV was found in patients with rheumatoid arthritis (30, 45 +/- 3, 04 U/L) compared to the control group (48, 37 +/- 1, 10 U/L) (p<0, 001). In contrast, serum DPP IV activities in patients with psoriatic arthritis (49, 96 +/- 3, 80 U/L) and osteoporosis (43, 11 +/- 3, 9 U/L) were not statistically significantly different from healthy controls. The decreased serum DPP IV activity in patients with rheumatoid arthritis suggests its possible involvement in the regulation of immune processes, which could lead to the disease occurrence. It could likewise be possibly involved in the disease progression.

Dipeptidyl Peptidase IV (DPP IV/CD26); Serum Activity; Rheumatoid Arthritis

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