Specific sensing of poly G by the aluminum– salophen complex (CROSBI ID 133325)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Cametti, Massimo ; Piantanida, Ivo ; Žinić, Mladen ; Dalla Cort, Antonella ; Mandolini, Luigi ; Marjanović, Marko ; Kralj, Marijeta
engleski
Specific sensing of poly G by the aluminum– salophen complex
The Al(III)– salophen complex 1 exhibited strong spectroscopic changes specifically upon addition of polyG and GpG, while double stranded DNA and RNA, and single stranded polyA, polyU and polyC induced negligible spectral changes of 1. Titrations with mononucleotides yielded no spectroscopic changes, revealing that there must be at least two consecutive guanines in single stranded oligonucleotide structure for a measurable spectroscopic change of 1. Preliminary results show that 1 has moderate antiproliferative effect on a number of human tumour cell lines.
salophen-metal complex; DNA; RNA; aluminum
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Podaci o izdanju
Povezanost rada
Kemija, Temeljne medicinske znanosti