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Pregled bibliografske jedinice broj: 303838

Population Substructure can Significantly Affect Reliability of a DNA-lead Process of identification of Mass Fatality Victims


Kračun, Stjepan Krešimir; Ćurić, Goran; Biruš, Ivan; Džijan, Snježana; Lauc, Gordan
Population Substructure can Significantly Affect Reliability of a DNA-lead Process of identification of Mass Fatality Victims // Journal of Forensic Sciences, 52 (2007), 4; 874-878 doi:10.1111/j.1556-4029.2007.00492.x (međunarodna recenzija, članak, znanstveni)


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Naslov
Population Substructure can Significantly Affect Reliability of a DNA-lead Process of identification of Mass Fatality Victims
(Population Substructure can Significantly Affect Reliability of a DNA-lead Process of Identification of Mass Fatality Victims)

Autori
Kračun, Stjepan Krešimir ; Ćurić, Goran ; Biruš, Ivan ; Džijan, Snježana ; Lauc, Gordan

Izvornik
Journal of Forensic Sciences (0022-1198) 52 (2007), 4; 874-878

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
forensic science; human identification; DNA typing; STR loci; population substructure; inbreeding; mini-haplotypes

Sažetak
Aiming to evaluate effects of population substructure on the reliability of a DNA correspondence in the process of human identification, we used model of "in silico" constructed populations with and without substructure. Effects of population substructure were evaluated at the level of locus heterozygosity, Hardy-Weinberg equilibrium, and mini-haplotype distribution. Inbreeding in a subpopulation of 100 individuals through 10 generations did not significantly alter level of heterozygosity, and Hardy-Weinberg equilibrium. However, analysis of mini-haplotype distribution revealed significant homogenization in separated subpopulations. Average observed mini-haplotype frequency (fo) increased to threefold from expected values (fe), and the number of mini-haplotypes with fo/fe above 10 increased over six-fold, suggesting that effects of population substructure on calculated likelihood ratios might be larger than previously estimated. In most criminal cases this would not represent a problem, but for identifications in large-scale mass fatality events, population substructure might considerably increase the risk of false identification.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom (Gordan Lauc, )

Ustanove
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Kračun, Stjepan Krešimir; Ćurić, Goran; Biruš, Ivan; Džijan, Snježana; Lauc, Gordan
Population Substructure can Significantly Affect Reliability of a DNA-lead Process of identification of Mass Fatality Victims // Journal of Forensic Sciences, 52 (2007), 4; 874-878 doi:10.1111/j.1556-4029.2007.00492.x (međunarodna recenzija, članak, znanstveni)
Kračun, S., Ćurić, G., Biruš, I., Džijan, S. & Lauc, G. (2007) Population Substructure can Significantly Affect Reliability of a DNA-lead Process of identification of Mass Fatality Victims. Journal of Forensic Sciences, 52 (4), 874-878 doi:10.1111/j.1556-4029.2007.00492.x.
@article{article, year = {2007}, pages = {874-878}, DOI = {10.1111/j.1556-4029.2007.00492.x}, keywords = {forensic science, human identification, DNA typing, STR loci, population substructure, inbreeding, mini-haplotypes}, journal = {Journal of Forensic Sciences}, doi = {10.1111/j.1556-4029.2007.00492.x}, volume = {52}, number = {4}, issn = {0022-1198}, title = {Population Substructure can Significantly Affect Reliability of a DNA-lead Process of Identification of Mass Fatality Victims}, keyword = {forensic science, human identification, DNA typing, STR loci, population substructure, inbreeding, mini-haplotypes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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