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Average evoked potentials and acetylcholine release in the somatosensory cortex of the cat treated with WR-2721

WR-2721 exerts the accentuated effect on the peak-to-peak amplitude of the somatosensory evoked cortical response resulted from the peripheral nerve stimulation in anaesthetized cats when applied directly to the cortical surface (20 mg/ml) or injected i.p. (200 mg/kg). The magnitude of the effect as well as the duration of changes provoked by WR-2721 are related to sex. Acetylcholinesterase inhibitor eserine (100 ug/ml) , applied locally to the cortex, diminished the maximal amplitude of the evoked response as well as the response to WR-2121, but was essential for the collection of the acetylcholine released from the somatosensory cortex into the superfusion fluid. Systemic application of WR-2121 (200 mg/kg i.p.) decreased the acetylcholine output (40-60 %) and significantly reduced (32 %) the recurrent inhibition of the monosynaptic reflex in the spinal cord of decerebrated cats painting at the anticholinergic action of WR-2721 affects the central neurotransmission to our belief most probably through the hypoxia induced in the central nervous system.

Chemical Radioprotection WR-2721; Somatosensory Evoked Response; Acetylcholine Release; Recurrent Inhibition

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