engleski

Comparative analysis of cognitive evoked potentials and motor reaction in the healthy subjects and patients on different antiepileptic therapies

It is well known that antiepileptic drugs have side effects on cognitive and behavioral functioning of treated patients. Our goal was to investigate their influence on cognitive evoked potentials peak latencies and patient reaction times to target stimuli for two different, acoustic and visual, stimulating paradigms. A control group of healthy subjects and two group of epileptic patients treated with antiepileptic drugs (carbomazepine, phenobarbitone) were compared. Group 1 patients had subtherapeutic and group 2 patients therapeutic drug concentration in the blood. Group 3 patients were treated with carbomazepine in a therapeutic dose for nonepileptic reason. The N1, P2, N2, P3a and P3b peak latencies as well as reaction time to the same target stimuli were analyzed. The results obtained for acoustic and visual stimulating paradigm did not show any significant differences suggesting that the simple acoustic paradigm could be used for screening. The hypothesis that antiepileptic drugs influence the parameters of cognitive evoked potentials when used as polytherapy was confirmed. The reaction time measured in the same group of subjects showed statistically significant, however, the effect on the reaction time of treated patients was even more pronounced. Study results were consistent with our thesis that this suitable neurophysiologic method could be successfully used as a screening method to asses the cognitive and motor state of antiepileptic treated patients.

cognitive evoked potentials; reaction time; epilepsy

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