engleski

Long term follow-up of visual evoked potential parameters in patients with multiple sclerosis

Multiple sclerosis (MS) is patohistologically manifested as demyselinisation and axonal degeneration of central nervous system. these pathologic changes in visual pathway where followed by use of visual evoked potentials (VEP). The VEP parameters as latency (myelin functional state) and amplitudes (amount of neurons involved) where followed by 4 successive recordings of the same patient group. The pattern reversal VEP parameters as: peak N75, P100 and N135 latencies and P100 and N135 amplitudes where analysed. Results gave evidence that at the beginning time course of MS demyelinisation along visual pathway is more pronounced above the level of N75 generator. Demyelinisation process, presented as VEP latencies prolongation is slow but permanent for neurons affected at the beginning of disease as well as for nonaffected neurons at the beginning of disease (1st recording) so that at 4th recording all detected peaks had prolonged latencies. Amplitude analysis of the 1st recording shows lower values for the neurons affected by demyelinisation, no significant changes for certain period of time (1st-2nd series) but later on sudden, sharp amplitude decline by MS time progression for both demyelinised and normal visual pathway neurons. According to study results the process of visual pathways demyelinisation in MS progresses slowly and uniformly, whereas axonal degeneration once initiated shows abrupt and fast progression.

VEP; multiple sclerosis

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