engleski

Dimethyl carbonate reactions under microwave irradiation

Dimethyl carbonate is, according to its properties and nontoxicity, an environmentally attractive alternative for phosgene, methyl iodide and dimethyl sulfate in carboxy-methylation or methylation reactions. The influence of temperature and solvent (CH3CN) on reactions of dimethyl carbonate withsubstituted phenols and anilines, under microwave irradiation, was investigated. The main purpose was to explore dimethyl carbonate selectivity as methylating or carboxymethylating agent, toward aromatic oxygen or nitrogen nucleophiles. It is known that the use of microwave irradiation allows conduction of organic reactions at much higher temperatures thanboiling point of solvent, which leads to higher reaction rates. However, dymethyl carbonate is an ambient electrophile and higher temperatures reduce its selectivity in reactions of diamino (or dihydroxy) derivatives, gave complex mixtures of products.

Dimethyl carbonate; Microwave synthesis

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