Enantiopure (9-Anthryl)(2-piperidyl)- and (9-Anthryl)(2-pyridyl)methanols – Their Use as Chiral Modifiers for Heterogeneous Hydrogenation of Keto Esters over Pt/Al2O3 (CROSBI ID 132433)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Solladié-Cavallo, Arlette ; Marsol, Claire ; Azyat, Khalid ; Roje, Marin ; Welch, Christopher ; Chilenski, Jennifer ; Taillasson, Philippe ; D'Orchymont, Hugues
engleski
Enantiopure (9-Anthryl)(2-piperidyl)- and (9-Anthryl)(2-pyridyl)methanols – Their Use as Chiral Modifiers for Heterogeneous Hydrogenation of Keto Esters over Pt/Al2O3
A route toward the synthesis of the erythro isomer of (9-anthryl)(2-piperidyl)methanol is presented as well as resolution and assignment of the structure (through NMR). The use of both the erythro and threo enantiopure isomers of this new amino alcohol, and its precursor [(9-anthryl)(2-pyridyl)methanol], as chiral modifiers for the Pt/Al2O3 hydrogenation of ethyl lactate showed that the erythro isomer is not necessa- rily the most efficient chiral modifier. This is probably because of the 9-anthryl group. The enantioselectivities that this compound provides are not, as one would expect, higher than those observed with the naphthyl group.
Amino alcohols; Chiral resolution; Chiral modifiers; Hydrogenation
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Podaci o izdanju
2007 (5)
2007.
826-830
objavljeno
1434-193X
1099-0690
10.1002/ejoc.200600734