Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy (CROSBI ID 132049)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Vučičević, Željko ; Degoricija, Vesna ; Alfirević, Zrinka ; Vukičević-Badouin Dina Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy // International journal of clinical pharmacology and therapeutics, 45 (2007), 5; 289-292

Podaci o odgovornosti

Vučičević, Željko ; Degoricija, Vesna ; Alfirević, Zrinka ; Vukičević-Badouin Dina

engleski

Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy

Objective was to report a case of fatal hyponatremia, marked hyperglycemia, and acute pancreatitis following simultaneous administration of paroxetine, fluphenazine, haloperidol and olanzapine. A 44-year-old non- diabetic male was admitted unconsciously, with severe hyponatremia, hyperglycemia and bradypnea. The patient had a history of long-term treatment with paroxetine, fluphenazine, haloperidol and olanzapine. Upon arrival, the plasma sodium level was 104 mmol/L, and blood glucose was 940 mg/dL. The therapy consisted of ventilatory support and intensive correction of hyponatremia and hyperglycemia. 2 hours later, hypotension and refractory cardiac arrest occured. The autopsy disclosed severe cerebral edema as cause of death, and a modest hemorrhagic pancreatitis. Paroxetine is a selective serotonin reuptake inhibitor which stimulates antidiuretic hormone (ADH) release and may cause the syndrome of inappropriate ADH secretion with consecutive hyponatremia. Fluphenazine and haloperidol may contribute to this syndrome. Fluphenazine, and particulary olanzapine are assiciated with an increased incidence of diabetes. Olanzapine has been reported as a risk factor for acute pancreatitis. The Naranjo probability scale was not applicable because of almost immediate lethal outcome. Polypharmacy increases the risk of various adverse reactions. Adverse effects of paroxetine and many antipsychotic drugs, such as hyponatremia and hyperglycemia, should be monitored periodically to prevent complications. The role of olanzapine in the etiology of acute pancreatitis remains to be evaluated.

hyponatremia; SIADH; antipsychotics

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

45 (5)

2007.

289-292

objavljeno

0946-1965

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost