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Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts


Ćaleta, Irena; Kralj, Marijeta; Marjanović, Marko; Karminski-Zamola, Grace
Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts // Monatshefte fuer Chemie, 139 (2008), 5; 569-573 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts

Autori
Ćaleta, Irena ; Kralj, Marijeta ; Marjanović, Marko ; Karminski-Zamola, Grace

Izvornik
Monatshefte fuer Chemie (0026-9247) 139 (2008), 5; 569-573

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Synthesis and antiproliferative evaluation; Novel Bis-Styrylbenzothiazol-3-ium Salts

Sažetak
A series of bis-styrylbenzothiazol-3-ium salts containing different substituents 4-12 were synthesized from 2-methylbenzothiazole by condensation of quaternary salts 1-3 with p-substituted benzaldehydes. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Synthesized compounds 4-12 were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds 4-6 and 9 showed the best cell growth inhibitory activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI