Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts (CROSBI ID 132004)
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Podaci o odgovornosti
Ćaleta, Irena ; Kralj, Marijeta ; Marjanović, Marko ; Karminski-Zamola, Grace
engleski
Synthesis and Antiproliferative Evaluation of Novel Bis-Styrylbenzothiazol-3-ium Salts
A series of bis-styrylbenzothiazol-3-ium salts containing different substituents 4-12 were synthesized from 2-methylbenzothiazole by condensation of quaternary salts 1-3 with p-substituted benzaldehydes. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Synthesized compounds 4-12 were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds 4-6 and 9 showed the best cell growth inhibitory activity.
Synthesis and antiproliferative evaluation; Novel Bis-Styrylbenzothiazol-3-ium Salts
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Podaci o izdanju
Povezanost rada
Kemija, Temeljne medicinske znanosti, Biologija